人妻少妇不满足中文字幕,午夜精品在线一区二区91,日韩国产欧美在线一区,秋霞电影院午夜伦A片,国产精品v?欧美精品免费,日韩午夜的免费理论片,97欧美在线看欧美视频免费,人妻一区二区三区不卡视频

Regulatory T (T-reg) cells are critical for immune tolerance but also form a barrier to antitumor immunity. As therapeutic strategies involving T-reg cell depletion are limited by concurrent autoimmune disorders, identification of intratumoral T-reg cell-specific regulatory mechanisms is needed for selective targeting. Epigenetic modulators can be targeted with small compounds, but intratumoral T-reg cell-specific epigenetic regulators have been unexplored. Here, we show that JMJD1C, a histone demethylase upregulated by cytokines in the tumor microenvironment, is essential for tumor T-reg cell fitness but dispensable for systemic immune homeostasis. JMJD1C deletion enhanced AKT signals in a manner dependent on histone H3 lysine 9 dimethylation (H3K9me2) demethylase and STAT3 signals independently of H3K9me2 demethylase, leading to robust interferon-gamma production and tumor T-reg cell fragility. We have also developed an oral JMJD1C inhibitor that suppresses tumor growth by targeting intratumoral T-reg cells. Overall, this study identifies JMJD1C as an epigenetic hub that can integrate signals to establish tumor T-reg cell fitness, and we present a specific JMJD1C inhibitor that can target tumor T-reg cells without affecting systemic immune homeostasis.