郵箱: wangsijia@sinh.ac.cn
電話: +86-21-54920559
研究組主頁: https://www.biosino.org/humanphenomics
所屬部門: 計算生物學重點實驗室
2017-至???今：中國科學院上海營養(yǎng)與健康研究所，研究員
2012-2016年：中國科學院-馬普學會計算生物學伙伴研究所，研究員
2009-2012年：美國哈佛大學，博士后
2003-2008年：英國倫敦大學，人類遺傳學，人類遺傳學博士
2002-2003年：英國杜勒姆大學，人類學，人類學碩士
皮膚基因組學、表型組學
????在Paul-Gerson-Unna皮膚基因組學課題組，我們開發(fā)及運用系統(tǒng)組學分析方法及人工智能算法，利用人群隊列產(chǎn)生的生物大數(shù)據(jù)，構(gòu)建皮膚等外貌相關(guān)表型與基因、環(huán)境及其它相關(guān)表型的互作網(wǎng)絡，建立預測個體健康狀況的算法模型。我們目前有三個研究焦點：
1. 開發(fā)并整合計算方法以定量皮膚及外貌相關(guān)表型。
2. 建模評估基因與環(huán)境的互作對皮膚及外貌相關(guān)表型的影響。
3. 探究皮膚及外貌相關(guān)表型的在人類進化中所受的適應性選擇。
1.?Kaiwen Wan, Lei Li, Dengqiang Jia, Shangqi Gao, Wei Qian, Yingzhi Wu, Huandong Lin, Xiongzheng Mu, Xin Gao, Sijia Wang, Fuping Wu, Xiahai Zhuang*. Multi-target landmark detection with incomplete images via reinforcement learning and shape prior embedding. Med Image Anal 2023 Oct:89:102875.
2.?Junyu Luo#, Qili Qian#, Wenxin Zheng#, Ieva Gripkauskaite, Sijie Wu, Min Zhang, Jinxi Li, Bingfei Fu, Ranjit Bhogal, Peter Murray, Matthew Rowson, Bin Li, Xiangyang Xue, Xuelan Gu, Yajun Yang, Li Jin, David Andrew Gunn*, Sijia Wang*. Scalp hair loss is not random across follicular units: A new insight into human hair ageing. Int J Cosmet Sci 2023 Aug;45(4):548-555.
3.?Qianqian Peng#, Yu Liu#, Anke Huels, Canfeng Zhang, Yao Yu, Wenqing Qiu, Xiyang Cai, Yuepu Zhao, Tamara Schikowski, Katja Merches, Yun Liu, Yajun Yang, Jiucun Wang, Yong Zhao, Li Jin, Liang Zhang, Jean Krutmann, Sijia Wang*. Genetic Variants in Telomerase Reverse Transcriptase Contribute to Solar Lentigines. J Invest Dermatol 2023 Jun;143(6):1062-1072.e25.
4.?Hailuan Zeng#, Jieyu Ge#, Wenjie Xu, Hui Ma, Lingyan Chen, Mingfeng Xia, Baishen Pan, Huandong Lin*, Sijia Wang*, Xin Gao*. Twelve loci associated with bone density in middle-aged and elderly Chinese: the Shanghai Changfeng Study. J Clin Endocrinol Metab 2023 Jan 17;108(2):295-305.
5.?Wei Qian#, Manfei Zhang#, Kaiwen Wan#, Yunxia Xie#, Siyuan Du, Jiarui Li, Xiongzheng Mu, Jiange Qiu, Xiangyang Xue, Xiahai Zhuang*, Yingzhi Wu*, Fan Liu*, Sijia Wang*. Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness. J Genet Genomics 2022 Oct;49(10):934-942.
6.?Jieyi Chen#, Ping Zhang#, Meifang Peng, Bo Liu, Xiao Wang, Siyuan Du, Yao Lu, Xiongzheng Mu, Yulan Lu*, Sijia Wang*, Yingzhi Wu*. An additional whole-exome sequencing study in 102 panel-undiagnosed patients: A retrospective study in a Chinese craniosynostosis cohort. Front Genet 2022 Sep 2;13:967688.
7.?Bingjie Li#, Ying Cheng#, Yimei Tan#, Fudi Wang, Weiyi Hu, Xuemin Wang, Wei Liu, Jean Krutmann, Sijia Wang*, Ying Zou*. Analysis of factors influencing skin reactions to sunscreens, skin whitening products, and deodorants: Results from a large-scale patch test dataset in China. J Cosmet Dermatol 2022 Sep;21(9):3986-3992.
8.?Yu Fan, Jinxi Li#, Shaoying Song, Haiguo Zhang, Sijia Wang*, Guangtao Zhai*. Palmprint Phenotype Feature Extraction and Classification Based on Deep Learning. Phenomics 2022 Jun 22;2(4):219-229.
9.?Sijie Wu#, Yao Yu#, Caiyue Liu#, Xia Zhang, Peiying Zhu, You Peng, Xinyu Yan, Yin Li, Peng Hua, Qingfeng Li*, Sijia Wang*, Liang Zhang*. Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying. Cell Discov 2022 May 24;8(1):49.
10.?Bingjie Li#, Ying Cheng#, Yimei Tan#, Fudi Wang, Weiyi Hu, Xuemin Wang, Wei Liu, Jean Krutmann, Sijia Wang*, Ying Zou*. Analysis of factors influencing patch test reactions: Results from a large- population-based study in Chinese. J Cosmet Dermatol 2022 May;21(5):2183-2188.
11.?Manfei Zhang#, Sijie Wu#, Siyuan Du#, Wei Qian#, Jieyi Chen, Lu Qiao, Yajun Yang, Jingze Tan, Ziyu Yuan, Qianqian Peng, Yu Liu, Nicolas Navarro, Kun Tang, Andrés Ruiz-Linares, Jiucun Wang, Peter Claes, Li Jin*, Jiarui Li*, Sijia Wang*. Genetic variants underlying differences in facial morphology in East Asian and European populations. Nat Genet 2022 Apr;54(4):403-411.
12.?Fudi Wang#, Qi Luo#, Yan Chen, Yu Liu, Ke Xu, Kaustubh Adhikari, Xiyang Cai, Jialin Liu, Yi Li, Xuyang Liu, Luis-Miguel Ramirez-Aristeguieta, Ziyu Yuan, Yong Zhou, Fu-Feng Li, Binghua Jiang, Li Jin, Andres Ruiz-Linares, Zhaohui Yang, Fan Liu, Sijia Wang*. A genome-wide scan on individual typology angle found variants at SLC24A2 associated with skin color variation in Chinese populations. J Invest Dermatol 2022 Apr;142(4):1223-1227.e14.
13.?Bingjie Li#, Marissa L Kamarck#, Qianqian Peng#, Fei-Ling Lim, Andreas Keller, Monique A M Smeets, Joel D Mainland*, Sijia Wang*. From musk to body odor Decoding olfaction through genetic variation. PLoS Genet 2022 Feb 3;18(2):e1009564.
14.?Jinxi Li#, James D Glover#, Haiguo Zhang#, Meifang Peng#, Jingze Tan, Chandana Basu Mallick, Dan Hou, Yajun Yang, Sijie Wu, Yu Liu, Qianqian Peng, Shijie C Zheng, Edie I Crosse, Alexander Medvinsky, Richard A Anderson, Helen Brown, Ziyu Yuan, Shen Zhou, Yanqing Xu, John P Kemp, Yvonne Y W Ho, Danuta Z Loesch, Lizhong Wang, Yingxiang Li, Senwei Tang, Xiaoli Wu, Robin G Walters, Kuang Lin, Ruogu Meng, Jun Lv, Jonathan M Chernus, Katherine Neiswanger, Eleanor Feingold, David M Evans, Sarah E Medland, Nicholas G Martin, Seth M Weinberg, Mary L Marazita, Gang Chen, Zhengming Chen, Yong Zhou, Michael Cheeseman, Lan Wang, Li Jin*, Denis J Headon*, Sijia Wang*. Limb development genes underlie variation in human fingerprint patterns. Cell 2022 Jan 6;185(1):95-112.e18.
15.?Bingjie Li#, Xiyang Cai#, Lizhong Wang#, Jiarui Li, Ying Zou, Gang Chen, Sijia Wang*. A Genome-Wide Association Study Finds Variants at 2p21 Associated with Self-Reported Sensitive Skin in the Han Chinese population. J Invest Dermatol 2022 Jan;142(1):243-247.e9.
16.?Hailuan Zeng, Chenhao Lin, Sijia Wang*, Yan Zheng*, Xin Gao*. Genetically predicted body composition in relation to cardiometabolic traits: a Mendelian randomization study. Eur J Epidemiol 2021 Nov;36(11):1157-1168.
17.?Hailuan Zeng, Jieyu Ge, Wenjie Xu, Hui Ma, Lingyan Chen, Mingfeng Xia, Baishen Pan, Huandong Lin*, Sijia Wang*, Xin Gao*. Type 2 diabetes is causally associated with reduced serum osteocalcin: A genome-wide association and Mendelian randomization study. J Bone Miner Res 2021 Sep;36(9):1694-1707.
18.?Yin Huang#, Dan Li#, Lu Qiao, Yu Liu, Qianqian Peng, Sijie Wu, Manfei Zhang, Yajun Yang, Jingze Tan, Shuhua Xu, Li Jin, Sijia Wang*, Kun Tang*, Stefan Grünewald*. A Genome-wide Association Study of Facial Morphology Identifies Novel Genetic Loci in Han Chinese. J Genet Genomics 2021 Mar 20;48(3):198-207.
19.?Yingzhi Wu#, Meifang Peng#, Jieyi Chen#, Jinlong Suo, Sihai Zou, Yanqing Xu, Andrew O.M.Wilkie, Weiguo Zou, Xiongzheng Mu*, Sijia Wang*. A custom-designed panel sequencing study in 201 Chinese patients with craniosynostosis revealed novel variants and distinct mutation spectra. J Genet Genomics 2021 Feb 20;48(2):167-171.
20.?Chenglong You, Sijie Wu, Shijie C Zheng, Tianyu Zhu, Han Jing, Ken Flagg, Guangyu Wang, Li Jin, Sijia Wang*, Andrew E Teschendorff*. A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes. Nat Commun 2020 Sep 22;11(1):4779.
21.?Yimei Tan#, Fudi Wang#, Guobiao Fan#, Yan Zheng, Bingjie Li, Ning Li, Yu Liu, Xuemin Wang, Wei Liu, Jean Krutmann*, Ying Zou, Sijia Wang*. Identification of factors associated with minimal erythema dose variations in a large-scale population study of 22 146 subjects. J Eur Acad Dermatol Venereol 2020 Jul;34(7):1595-1600.
22.?Yu Liu#, Wenshan Gao#, Claudia Koellmann, Sigrid Le Clerc, Anke Huls, Bingjie Li, Qianqian Peng, Sijie Wu, Anan Ding, Yajun Yang, Li Jin, Jean Krutmann, Tamara Schikowski*, Jean-Francois Zagury*, Sijia Wang*. Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. J Dermatol Sci 2019 Oct;96(1):42-49.
23.?Lu Qiao, Yajun Yang, Pengcheng Fu, Sile Hu, Hang Zhou, Shouneng Peng, Jingze Tan, Yan Lu, Haiyi Lou, Dongsheng Lu, Sijie Wu, Jing Guo, Li Jin, Yaqun Guan, Sijia Wang*, Shuhua Xu*, Kun Tang*. Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction. J Genet Genomics 2018 Aug 20;45(8):419-432.
24.?Sijie Wu#, Manfei Zhang#, Xinzhou Yang#, Fuduan Peng, Juan Zhang, Jingze Tan, Yajun Yang, Lina Wang, Yanan Hu, Qianqian Peng, Jinxi Li, Yu Liu, Yaqun Guan, Chen Chen, Merel A. Hamer, Tamar Nijsten, Changqing Zeng, Kaustubh Adhikari, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria Catira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-Jose, Hui Li, Jean Krutmann, Fan Liu, Manfred Kayser, Andres Ruiz-Linares, Kun Tang, Shuhua Xu, Liang Zhang*, Li Jin*, Sijia Wang*. Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLoS Genet 2018 Sep 24;14(9):e1007640.
25.?John R. Shaffer#, Jinxi Li#, Myoung Keun Lee, Jasmien Roosenboom, Ekaterina Orlova, Kaustabh Adhikari, 23andMe Research Team, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria Catira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-Jose, Paige E. Pfeffer, Christopher A. Wollenschlaeger, Jacqueline T. Hecht, George L. Wehby, Lina M. Moreno, Anan Ding, Li Jin, Yajun Yang, Jenna C. Carlson, Elizabeth J. Leslie, Eleanor Feingold, Mary L. Marazita, David A. Hinds, Timothy C. Cox, Sijia Wang*, Andres Ruiz-Linares, Seth M. Weinberg*. Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment. Am J Hum Genet 2017 Dec 7;101(6):913-924.
26.?Anan Ding#, Yajun Yang#, Zhuohui Zhao#, Anke Huls, Andrea Vierkotter, Ziyu Yuan, Jing Cai, Juan Zhang, Wenshan Gao, Jinxi Li, Manfei Zhang, Mary Matsui, Jean Krutmann, Haidong Kan, Tamara Schikowski*, Li Jin*, Sijia Wang*. Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population. Sci Rep 2017 Nov 10;7(1):15329.
27.?Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*. Genetic history of Xinjiang's Uyghurs suggests Bronze Age multiple-way contacts in Eurasia. Mol Biol Evol 2017 Oct 1;34(10):2572-2582.
28.?Wenshan Gao#, Jingze Tan#, Anke Huls#, Anan Ding, Yu Liu, Mary S. Matsui, Andrea Vierkotter, Jean Krutmann, Tamara Schikowski*, Li Jin*, Sijia Wang*. Genetic variants associated with skin aging in the Chinese Han population. J Dermatol Sci 2017 Apr;86(1):21-29.
29.?Manfei Zhang#, Bingjie Li#, Sijie Wu, Jingze Tan, Yajun Yang, Alessandra Marini, Andrea Vierkotter, Juan Zhang, Hui Li, Tamara Schikowski, Li Jin, Jean Krutmann, Sijia Wang*. A genome-wide association study of basal transepidermal water loss finds variants at 9q34.3 to be associated with skin barrier function. J Invest Dermatol 2017 Apr;137(4):979-982.
30.?Manfei Zhang#, Sijie Wu#, Juan Zhang#, Yajun Yang#, Jingze Tan, Yu Liu, Haijuan Guan, Kun Tang, Jean Krutmann, Shuhua Xu, Li Jin, Yaqun Guan*, Hui Li*, Sijia Wang*. Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. J Genet Genomics 2016 Dec 20;43(12):702-704.
31.?Sijie Wu#, Jingze Tan#, Yajun Yan#, Qianqian Peng, Manfei Zhang, Jinxi Li, Dongsheng Lu, Yu Liu, Haiyi Lou, Qidi Feng, Yan Lu, Yanqun Guan, Zhaoxia Zhang, Yi Jiao, Pardis Sabeti, Jean Krutmann, Kun Tang, Li Jin*, Shuhua Xu*, Sijia Wang*. Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet 2016 Nov;135(11):1279-1286.
32.?Anke Huls#, Andrea Vierkotter#, Wenshan Gao#, Ursula Kramer, Yajun Yang, Anan Ding, Sabine Stolz, Mary Matsui, Haiong Kan, Li Jin*, Sijia Wang*, Jean Krutmann*, Tamara Schikowski. Traffic-Related Air Pollution Contributes to Development of Facial Lentigines: Further Epidemiological Evidence from Caucasians and Asians. J Invest Dermatol 2016 May;136(5):1053-1056.
33.?Lian Deng, Andres Ruiz-Linares, Shuhua Xu*, Sijia Wang*. Ancestry variation and footprints of natural selection along the genome in Latin American populations. Sci Rep 2016 Feb 18;6:21766.
34.?Qianqian Peng#, Jinxi Li#, Jingze Tan#, Yajun Yang#, Manfei Zhang, Sijie Wu, Yu Liu, Juan Zhang, Pengfei Qin, Yaqun Guan, Yi Jiao, Zhaoxia Zhang, Pardis C. Sabeti, Kun Tang, Shuhua Xu, Li Jin*, Sijia Wang*. EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects. Hum Genet 2016 Jan;135(1):99-108.
35.?Miaozhu Li#, Andrea Vierkotter#, Tamara Schikowski#, Anke Huls, Anan Ding, Mary S. Matsui, Binwei Deng, Chuan Ma, Aiguo Ren, Juan Zhang, Jingze Tan, Yajun Yang, Li Jin, Jean Krutmann*, Zhiwen Li*, Sijia Wang*. Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women. J Dermatol Sci 2015 Aug;79(2):148-154.
36.?Jingze Tan#, Qianqian Peng#, Jinxi Li#, Yanqun Guan, Liping Zhang, Yi Jiao, Yajun Yang, Sijia Wang*, Li Jin*. Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant. Sci China Life Sci 2014 May;57(5):510-518.
37.?Jingze Tan#, Yanjun Yang#, Kun Tang, Pardis C.Sabeti, Li Jin*, Sijia Wang*. The adaptive variant EDARV370A is associated with straight hair in East Asians. Hum Genet 2013 Oct;132(10):1187-1191.
38.?Yana G. Kamberov#, Sijia Wang#, Jingze Tan, Pascale Gerbault, Abigail Wark, Longzhi Tan, Yajun Yang, Shilin Li, Kun Tang, Hua Chen, Adam Powell, Yuval Itan, Dorian Fuller, Jason Lohmueller, Junhao Mao, Asa Schachar, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas, Daniel E. Lieberman, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas,Daniel E. Lieberman, Li Jin*, Clifford J. Tabin, Bruce A. Morgan*, Pardis C. Sabeti*, Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell 2013 Feb 14;152(4):691-702.
39.?Sijia Wang*, Gabriel Bedoya, Damian Labuda, Andres Ruiz-Linares*. Brief communication: patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations. Am J Phys Anthropol 2010 Jul;142(3):476-480.
40.?Sijia Wang, Nicolas Ray, Winston Rojas, Maria V. Parra, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Guido Mazzotti, Kim Hill, Ana M.Hurtado, Beatriz Camrena, Humberto Nicolini, William Klitz, Ramiro Barrantes, Julio A. Molina, Nelson B. Freimer, Maria Catira Bortolini, Francisco M. Salzano, Maria L. Petzl-Erler, Luiza T. Tsuneto, Jose E. Dipierri, Emma L. Alfaro, Graciela Bailliet, Nestor O. Bianchi, Elena Llop, Francisco Rothhammer, Laurent Excoffier*, Andres Ruiz-Linares*. Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet 2008 Mar 21;4(3):e1000037.
41.?Sijia Wang#, Cecil M. Lewis Jr#, Mattias Jakobsson#, Sohini Ramachandran, Nicolas Ray, Gabriel Bedoya, Winston Rojas, Maria V. Parra, Julio A. Molina, Carla Gallo, Guido Mazzotti, Giovanni Poletti, Kim Hill, Ana M.Hurtado, Damian Labuda, William Klitz, Ramiro Barrantes, Maria Catira Bortolini, Francisco M. Salzano, Maria Luiza Petzl-Erler, Luiza T. Tsuneto, Elena Llop, Francisco Rothhammer, Laurent Excoffier, Marcus W. Feldman, Noah A. Rosenberg*, Andres Ruiz-Linares*. Genetic variation and population structure in Native Americans. PLoS Genet 2007 Nov;3(11):e185.
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